Masters Project Defense: “Detection of Copy Number Variations in Cancer Genomes via Entropic Dissection” | Department of Mathematics

Masters Project Defense: “Detection of Copy Number Variations in Cancer Genomes via Entropic Dissection”

Event Information
Event Location: 
GAB 438
Event Date: 
Wednesday, July 3, 2013 - 2:30pm
Professor Rajeev Azad invites you to attend the Masters project defense of Miah JnCharles on Wednesday, July 3rd at 2:30 pm in GAB 438. Cookies and coffee will be served in GAB 472 following this event. "Detection of Copy Number Variations in Cancer Genomes via Entropic Dissection" Abstract: Copy number variations (CNVs), a class of structural variations, are alterations in DNA that cause an abnormal number of DNA copies in one or more regions in the genome of an organism. Like other types of genetic variations, CNV have been associated with susceptibility to disease. Identifying copy number variants in cancer genomes, i.e. regions with DNA amplification or deletion, is important for locating cancer related genes. Several methods have been developed to identify such variants. We use an information entropy based measure in the framework of a recursive segmentation and clustering method to identify these variants. We characterize CNV in array Comparative Genome Hybridization (aCGH) as well as Single Nucleotide Polymorphism (SNP) array data.