Reconstructing the Genomic Architecture of Ancestral Mammals | Department of Mathematics

Reconstructing the Genomic Architecture of Ancestral Mammals

Event Information
Event Location: 
GAB 461, 4-5 PM; Refreshments: GAB 472, 3:30 PM
Event Date: 
Monday, November 7, 2011 - 4:00pm
In addition to frequent single-nucleotide mutations, mammalian and many other genomes undergo rare and dramatic changes in their chromosomal organization, called genome rearrangements. These include inversions, fissions, fusions, and translocations. Although analysis of genome rearrangements was pioneered by Dobzhansky and Sturtevant in 1938, we still know very little about the rearrangement events that produced the existing varieties of genomic architectures. Recovery of mammalian rearrangement history is a difficult combinatorial problem that I will cover in this talk.